Japanese experts say an enzyme that causes obesity or promotes weight loss drug development
Japan's Institute of basic biology and other research team announced 14, has been successfully found in the brain feeding center work, and become the cause of obesity enzymes. The enzyme is also said to inhibit the work of insulin that lowers blood sugar levels. Professor Noda Masaharu, a professor of Neurobiology at the Institute, said: "if you develop drugs that inhibit the action of enzymes, you can improve obesity and diabetes."."
According to the team, in the human body, a hormone called "leptin" secreted from fat cells acts on the feeding center and adjusts food intake, but food intake may not be suppressed in obese people. Although the reason is that the "lean protein" is difficult to function, it is not clear the specific mechanism.
The team focused on enzymes that work on the surface of nerve cells in the feeding center and take part in various signaling pathways, and found an enzyme called PTPRJ that inhibits the work of leptin.
Reported that, for normal mice and PTPRJ mice fed with enzyme 14 weeks high fat foods into obese state, and then for a week into "leptin", normal rats weigh almost no change, but not the PTPRJ enzyme of mice are about half the weight loss of appetite, also reduced by about 20%. According to the analysis, this is because the latter "lean protein" is not inhibited by PTPRJ enzymes.
According to the team, in the human body, a hormone called "leptin" secreted from fat cells acts on the feeding center and adjusts food intake, but food intake may not be suppressed in obese people. Although the reason is that the "lean protein" is difficult to function, it is not clear the specific mechanism.
The team focused on enzymes that work on the surface of nerve cells in the feeding center and take part in various signaling pathways, and found an enzyme called PTPRJ that inhibits the work of leptin.
Reported that, for normal mice and PTPRJ mice fed with enzyme 14 weeks high fat foods into obese state, and then for a week into "leptin", normal rats weigh almost no change, but not the PTPRJ enzyme of mice are about half the weight loss of appetite, also reduced by about 20%. According to the analysis, this is because the latter "lean protein" is not inhibited by PTPRJ enzymes.
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